• NEBANNER

Hot Sale for Polyvinylpyrrolidone K30 - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN

Hot Sale for Polyvinylpyrrolidone K30 - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Our eternal pursuits are the attitude of "regard the market, regard the custom, regard the science" and the theory of "quality the basic, trust the first and management the advanced" for Ultra Hydrophobic Material, Multimodal Anesthesia, Non Opioid Analgesics, We have a big inventory to fulfill our customer's demands and needs.
Hot Sale for Polyvinylpyrrolidone K30 - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN Detail:

12.The intermediate 4-(4-aminophenyl)-3-morpholinone (1) of the anticoagulant rivaroxaban was prepared by two methods: ①Bromobenzene was successively reacted with ethanolamine and chloroacetyl chloride to obtain 4-benzene The morpholinone is then nitrated to reduce to 1, and the total yield is about 32%; ②Bromobenzene is first nitrated, and then reacted with ethanolamine to obtain 2-(4-nitroanilino)ethanol, which is then closed by chloroacetyl chloride. The reduction reaction produces 1, and the total yield is about 47%.

Rivaroxaban is a new type of anticoagulant that can be directly taken orally. It directly inhibits the activation of coagulation factor Xa, has a definite anticoagulant effect, does not require continuous monitoring, and has high safety. With the clinical application of rivaroxaban , The demand for rivaroxaban will gradually increase. The chemical name of rivaroxaban is 5-chloro-N-(((5S) -2-oxo-3-[4- (3-oxo- 4-morpholinyl)phenyl)-1,3-oxazolidine-5-yl)methyl-2-thiophenecarboxamide. There are currently two synthetic routes reported in the literature, and both routes are used An intermediate 4-(4-aminophenyl)-3-morpholinone. Although there are reports on the synthesis of 4-(4-aminophenyl)-3-morpholinone at home and abroad, there is a relatively high price of reaction raw materials. High, difficult to buy, or the reaction operation requirements are too high, difficult to grasp, not conducive to environmental protection and other deficiencies, and do not meet the requirements of industrialized mass production. Optimize the key intermediate of rivaroxaban 4-(4-aminophenyl)- The production process of 3-morpholinone and the reduction of the price of raw materials will definitely promote the promotion and application of rivaroxaban. There is no report on the synthesis of rivaroxaban in China. We are at rivaroxaban The key intermediate 4-(4-aminophenyl)-3-morpholinone synthetic route and technology have been innovatively studied. Two bromobenzene and p-nitrobromobenzene as starting materials are proposed. Process route. Focus on the cyclization process of 3-morpholinone ring.

Executive standard: enterprise standard
Exterior: White crystalline powder

Package: 25kg/drum
assay(HPLC)Content greater than or equal to 98.0%


Product detail pictures:

Hot Sale for Polyvinylpyrrolidone K30 - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN detail pictures


Related Product Guide:

To consistently enhance the management method by virtue of the rule of "sincerely, fantastic religion and top quality are the base of business development", we extensively absorb the essence of associated goods internationally, and constantly acquire new merchandise to satisfy the needs of shoppers for Hot Sale for Polyvinylpyrrolidone K30 - 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride – JIN DUN , The product will supply to all over the world, such as: Mozambique, Orlando, Algeria, To have much more enterprise. ompanions, we've got updated the item list and seek for optimistic co-operation. Our web-site shows the latest and complete information and facts about our merchandise list and company. For further acknowledge, our consultant service group in Bulgaria will reply to all of the inquiries and complications immediately. They're about to make their finest effort to meet buyers need. Also we support the delivery of absolutely free samples. Business visits to our business in Bulgaria and factory are generally welcome for a win-win negotiation. Hope to expertise a happy company co-operation perform with you.
  • The factory workers have rich industry knowledge and operational experience, we learned a lot in working with them,we are extremely grateful that we can encount a good company has excellent wokers.
    5 Stars By Lauren from El Salvador - 2018.11.22 12:28
    Wide range, good quality, reasonable prices and good service, advanced equipment, excellent talents and continuously strengthened technology forces,a nice business partner.
    5 Stars By Antonio from Sydney - 2017.06.22 12:49
    Write your message here and send it to us
    TOP