Manufacturing Companies for Water Filter And Softener - 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3 – JIN DUN

Short Description:

Product Detail

Product Tags

Feedback (2)

"Control the standard by the details, show the toughness by quality". Our firm has strived to establish a highly efficient and stable workers workforce and explored an effective high-quality management system for Wastewater Treatment Process Steps, 2 6-Dichloro-5-Fluoronicotinic Acid, Rivaroxaban And Prasugrel Etc, We're prepared to present you with the most effective ideas over the designs of the orders in a qualified way for those who need. While in the meantime, we continue to keep on producing new technologies and building new designs so as to help make you ahead from the line of this small business.

Manufacturing Companies for Water Filter And Softener - 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3 – JIN DUN Detail:

Use: Intermediate for Linagliptin.

Use：Intermediate for Linagliptin
Executive standard： enterprise standard
Assay：98-102%

Exterior：White to light yellow powder
Package: 25kg/drum

To analyze the existing linagliptin and its key intermediate 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl -2-quinazolinyl)methyl)-1H-purine-2,6-dione (11) synthesis method, find a synthetic route suitable for industrial production. Method: summarize the different synthetic routes. Results and conclusions: Route 2.2 has a relatively simple process and lower cost, which is more suitable for industrial production.

8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione is a key intermediate in the synthesis of the hypoglycemic drug linagliptin. The synthesis of 1 uses methyl urea and cyanoacetic acid as starting materials, and undergoes six-step reactions of condensation, cyclization, nitrosation, reduction, cyclization, and bromine with a total yield of 46.3%. The structures of all intermediates were confirmed by 1HNMR.

The present invention relates to a simple preparation method of high-purity linagliptin. Quinazoline, the key intermediate for the one-pot preparation of linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, the intermediate is separated by filtration, and then reacted with (R)3 aminopiperidine dihydrochloride to obtain a solution containing linagliptin. After the solution containing linagliptin is processed again, Deliraliptin pure product. The preparation of the key intermediate of the present invention adopts a one-pot method, which is convenient to operate and improves the yield. After the key intermediate is separated, it is reacted with (R)3 aminopiperidine dihydrochloride, thereby Obtaining high-purity linagliptin also meets the production and declaration requirements of pharmaceutical companies to the greatest extent.

Product detail pictures:

Related Product Guide:

No matter new buyer or old purchaser, We believe in long expression and trusted relationship for Manufacturing Companies for Water Filter And Softener - 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3 – JIN DUN , The product will supply to all over the world, such as: Islamabad, Hamburg, Bandung, We have got constantly insisted on the evolution of solutions, spent good funds and human resource in technological upgrading, and facilitate production improvement, meeting the wants of prospects from all countries and regions.

Analgesia Pancreatitis

Antipsychotic Tablets

Bod Wastewater Treatment

Boiler Water Treatment Chemicals

Diy Crystal Glue

Hvac Cooling Tower Water Treatment

Metal Vacuum Coating Uv Primer

Paliperidone Palmitate

Steps Involved In Wastewater Treatment

Tertiary Treatment Of Water

Managers are visionary, they have the idea of "mutual benefits, continuous improvement and innovation", we have a pleasant conversation and Cooperation.