Hydroxypyrazolodpyrimidine pyrazolo(3,4-d)pyrimidin-1-ol
Hydroxypyrazolodpyrimidine pyrazolo(3,4-d)pyrimidin-1-ol
It is clinically used in primary and secondary Hyperuricemia, especially in patients with hyperuricemia, as well as in patients with renal insufficiency, and in patients with recurrent or chronic gout, as well as in patients with Hyperuricemia. Used in patients with Gouty nephropathy to relieve symptoms and reduce the formation of renal uric acid stones; gout stones; used in uric acid kidney stones and uric acid kidney disease.
This product and its metabolites can inhibit xanthine oxidase, so that hypoxanthine and xanthine cannot be converted into uric acid, that is, the synthesis of uric acid is reduced, thereby reducing the concentration of uric acid in the blood and reducing the concentration of urate in the bones, Joints and kidneys, drugs that can inhibit the synthesis of uric acid. This product can inhibit the activity of liver drug enzymes.
(1) . Primary and secondary hyperuricemia, especially those with excessive uric acid production, are also used for hyperuricemia with renal insufficiency;
(2) . For the treatment of gout, suitable for recurrent or chronic gout. For patients with gouty nephropathy, it can relieve symptoms and reduce the formation of uric acid stones in the kidneys;
(3) . Tophi;
(4) . Used for uric acid kidney stones and (or) uric acid nephropathy.
Standard：usp42
Assay：98-102%
Exterior：White or almost white powder
Package : 25kg/bag
There is bone marrow suppression, which can cause pancytopenia, and the drug should be discontinued if necessary. Drink plenty of water during the medication, and make the urine neutral or alkaline to excrete diuretic acid. This product must be applied after the acute inflammation of gouty arthritis disappears (usually about two weeks after the onset). During medication, blood picture and liver and kidney function should be checked regularly.
JIN DUN Medical has ISO qualification and meets GMP production standards, employed domestic and foreign drug synthesis experts with rich experience to guide company's R&D.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation . High Pressure Hydrogenolysis Reaction . Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
●Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira . Gignard Reaction
Equipments
Our Lab has various experimental and testing equipments, such as: NMR (Bruker 400M)、HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000)、IR、UV、GC、GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Team
Jindun Medical has a group of professional R&D personnel, and employs many domestic and foreign drug synthesis experts to guide R&D, making our synthesis more accurate and efficient.
We have helped several top domestic pharmaceutical companies, such as Hansoh, Hengrui and HEC Pharm. Here we will show part of them.
Customzation Case One:
Cas No.: 110351-94-5
Customzation Case Two:
Cas No.: 144848-24-8
Customzation Case Three:
Cas No.: 200636-54-0
1.Customize New Intermediates or APIs. Same as above case sharing, customers have the demands for specific Intermediates or APIs, and they can not find the needed products in the market, then we can help to Customize.
2.Process Optimization for Old Products. Our team will help to Optimize and improve such production whose reaction route is old, production cost is high, and the efficiency is low. We can provide full documentation for technology transfer and process improvement, help customer for a more efficient production.
From drug targets to INDs, JIN DUN Medical provides you with one-stop personalized R&D solutions.
JIN DUN Medical insists on creating a team with dreams, making dignified products, meticulous, rigorous, and going all out to be a trusted partner and friend of customers!
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